Abstract #4334

Para-hydrogen signal-enhanced 1-13C-pyruvate-d3 for rapid metabolic tumor imaging

Henning Schroeder¹, Theresa Hune¹, Salvatore Mamone¹, Anil Jagtap¹, Sonja Sternkopf¹, Gabriele Stevanato¹, Sergey Korchak¹, Claudia Fokken², Christoph Müller^3,4, Dorothea Becker², Andreas Schmidt^3,4,5, and Stefan Glöggler¹

¹NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, ²Department of NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, ³Division of Medical Physics, Department of Radiology, Medical Center, University of Freiburg, Freiburg, Germany, ⁴German Cancer Consortium (DKTK), partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Intergrative Biosciences (Ibio), Department of Chemistry, Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), CancerUsing a Parahydrogen-induced polarization (PHIP) based approach, we enhanced the signal of pyruvate, one of the key metabolites for energy production in the body. By injecting this metabolite into a mouse carrying a human melanoma tumor, we could perform real time spectroscopy and visualization of the tumors metabolism using a NMR machine. This offers a fast and powerful tool for metabolic imaging without using radio tracers.

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