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Abstract #4336

Quantitative Evaluation of kPL Dependence on Pyruvate Concentration in Anaplastic Thyroid Cancer Cell Suspensions using Hyperpolarized 13C NMR

Collin J. Harlan1,2, Yunyun Chen3, Gary V. Martinez2, Vlad C. Sandulache4, Stephen Y. Lai3,5,6, and James A. Bankson1,2
1The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States, 2Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, United States, 5Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 6Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Translational StudiesMetabolic imaging of hyperpolarized pyruvate can provide new insight into tumor progression and response to therapy. Pharmacokinetic modeling can be used to determine kPL, the apparent rate constant for conversion of hyperpolarized pyruvate into lactate. In this work, we sought to characterize the effect of hyperpolarized pyruvate concentration on intracellular kPL in ATC cell suspensions using a two-compartment pharmacokinetic model for kPL quantification. Improved understanding of the effects of concentration on intracellular chemical conversion rates could lead to more accurate quantification of in vivo and clinical hyperpolarized MRI imaging biomarkers of metabolism.

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