Abstract #4341

Towards Biomedical Applications of Parahydrogen Induced Polarization by Side-Arm Hydrogenation Using SAMBADENA

Henri de Maissin^1,2, Obaid Mohiuddin¹, Marvin Herzog¹, Eduard Y. Chekmenev^3,4, Sergey Korchak^5,6, Stefan Glöggler^5,6, Jan-Bernd Hövener⁷, Maxim Zaitsev¹, Dominik v. Elverfeldt¹, and Andreas B. Schmidt^1,3,8

¹Division of Medical Physics, University Medical Center Freiburg, Freiburg im Breisgau, Germany, ²German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany, ³Integrative biosciences (Ibio), department of Chemistry, Wayne state university, Detroit, MI, United States, ⁴Russian Academy of Sciences (RAS), Moscow, Russian Federation, ⁵NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, ⁶Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany, ⁷Section Biomedical Imaging, Molecular Imaging North Competence Center, Kiel, Germany, ⁸German Cancer Consortium (DKTK), Heidelberg, Germany

Synopsis

Keywords: High-Field MRI, Hyperpolarized MR (Non-Gas), parahydrogen cancer spectroscopyParahydrogen-induced Polarization (PHIP) by Synthesis Amid the Magnet Bore Allows Dramatically Enhanced Nuclear Alignment (SAMBADENA) of agents in situ within the MRI magnet and requires very little hardware in addition to the MRI system. However, side-arm hydrogenation (PHIP-SAH), fast side-arm cleavage and purification have not been attempted yet.
Here, we present a SAMBADENA setup made from commercially-available components for future preclinical applications. Using this setup, we demonstrate high ¹³C polarizations of 17% for 25mM ethyl-[1-¹³C]-acetate. In addition, for ethyl-pyruvate, fast side-arm cleavage and removal of 96% of the organic solvent within 10s to obtain pyruvate in neat water is demonstrated.

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