Abstract #4368

Relaxation Anisotropy Mapping of Articular Cartilage at 3 T

Ville Kantola^1,2, Jouni Karjalainen^1,2, Victor Casula^1,2, Mikko J. Nissi³, and Miika T. Nieminen^1,2,4

¹Research Unit of Health Science and Technology, University of Oulu, Oulu, Finland, ²Medical Research Center, University of Oulu, Oulu, Finland, ³University of Eastern Finland, Kuopio, Finland, ⁴Department of Diagnostic Radiology, University of Oulu, Oulu, Finland

Synopsis

Keywords: Cartilage, Relaxometry, Relaxation anisotropyThe study of T₂ and T_1ρ anisotropy in musculoskeletal tissues, arising from the orientation of collagen fibrils in tissue, has so far been limited to experimental MRI systems. Here we present a method for measuring relaxation anisotropy ex vivo on a clinical MRI system. Furthermore, we aimed to quantify and compare the degrees of orientation dependence in bovine articular cartilage through anisotropy mapping. T₂ and T_1ρ mapping was performed on bovine stifle joint samples at multiple sample orientations. After coregistration anisotropy maps were created using Michelson contrast. The results showed large variations in anisotropy across cartilage thickness and topographical locations.

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