Abstract #4369

Assessment of articular cartilage in response to an impact injury using µMRI

Amanveer Singh¹, Hannah Mantebea², Farid Badar², Syeda Batool², Gabrielle Abdelmessih³, Talia Sebastian³, Michael Newton⁴, and Yang Xia²

¹Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, United States, ²Department of Physics and Center for Biomedical Research, Oakland University, Rochestor, MI, United States, ³Department of Chemistry, Oakland University, Rochestor, MI, United States, ⁴Beaumont Hospital, Royal Oak, MI, United States

Synopsis

Keywords: Cartilage, Osteoarthritis, Osteoarthritis, Cartilage, Impact injuryThis project aimed to study the properties of articular cartilage in response to mechanical injury in rabbit knees using μMRI. Femoral cartilage bone plugs were excised 2 and 14 weeks after impact and imaged using μMRI at a resolution of 11.7 μm/pixel. Higher T2 relaxation values in affected specimens illustrated deterioration in the cartilage after impact. Furthermore, the higher T2 values in impacted samples of the 14-week batch compared to the 2-week batch indicate progressive cartilage degradation over time.

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