Abstract #4378
RADIOMICS FEATURES OF INFRAPATELLAR FAT PAD ASSOCIATED WITH POST-TRAUMATIC OSTEOARTHRITIS AT 10+ YEARS AFTER ACL RECONSTRUCTION
Sameed Khan1,2,3, Richard Lartey1,2, Nancy Obuchowski1,4, Sibaji Gaj1,2, Jee Hun Kim1,2, Mei Li1,2, Brendan Eck1,3, Carl S. Winalski1,2,3, Faysal Altahawi1,3, Morgan H Jones5, Laura J Huston6, Kevin D Harkins7, Michael V Knopp8, Christopher C Kaeding9, Kurt Spindler1,10, and Xiaojuan Li1,2,3
1Program of Advanced Musculoskeletal Imaging, Lerner Research Institute, Cleveland, OH, United States, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, United States, 3Department of Diagnostic Radiology, Imaging Institute, Cleveland, OH, United States, 4Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, United States, 5Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, United States, 6Department of Orthopedics and Rehabilitation, Vanderbilt University, Nashville, TN, United States, 7Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 8Wright Center of Innovation in Biomedical Imaging, Ohio State University, Columbus, OH, United States, 9Department of Orthopedic Surgery, The Ohio State University, Columbus, OH, United States, 10Department of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, United States
Synopsis
Keywords: Osteoarthritis, Fat
ACL injury is a major risk factor for post-traumatic osteoarthritis (PTOA), however mechanisms are not fully understood. In this work, we use radiomics from quantitative MRI imaging to associate subvisual changes in the infrapatellar fat pad (IPFP) to both symptomatic and radiographic PTOA. MRI was collected from 113 patients at least 10 years post-ACLR. 1690 radiomics and 11 clinical features were extracted and selected using a gradient-boosted decision tree classifier model. A subset of texture-associated features of IPFP and no clinical features were associated with symptomatic PTOA with an AUROC of 0.74 and radiographic PTOA with an AUROC of 0.84.
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