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Abstract #4387

Advanced RF antenna arrangements to improve the efficacy of Thermal Magnetic Resonance of Glioblastoma Multiforme at 7.0T, 9.4Tand 10.5T

Nandita Saha1,2, Andre Kuehne3, Jason M. Millward1, and Thoralf Niendorf1,4
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2The Charité – Universitätsmedizin, Berlin, Germany, 3MT MedTech Engineering GmbH, Berlin, Germany, 4Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Synopsis

Keywords: Interventional Devices, MR-Guided Interventions, Thermal MRThis work proposes the concept of four RF applicators combining SGBT dipole and loop building block antenna array for diagnostic proton (1H) imaging and thermal intervention at 7.0T, 9.4T and 10.5T. We demonstrated the relationship between spatial arrangement of the antennas in RF applicator and the SAR profile which further related to temperature rise for targeted thermal intervention of deep-seated brain tumors. This approach of design, simulation, optimization of EM power deposition followed by calculation of the resulting temperature distribution can be adapted as a pre-routine to conduct optimization result for individual patient for further treatment planning.

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