Keywords: Multimodal, Molecular Imaging, MRI Near Infrared RayPhotodynamic therapy is a non-invasive and controllable modality with potential as a novel cancer treatment strategy. However, the ROS production efficiency of PDT is restricted to hydrophobic characteristics and aggregation caused quenching of PSs. Herein, we designed a ROS self-activatable polymer (PTKPa) to suppress photosensitizers ACQ and elevate ROS production capacity. This platform shows therapeutic outcomes in both cells and orthotopic mouse model, which can significantly elevate the intracellular ROS level upon 660nm laser irradiation, induce immunogenic cell death (ICD) to activate antitumor immunity. This work provides a general strategy enhancing tumor photodynamic therapeutic effects.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords