Abstract #4440

The PRISM clinical trial: Quantitative imaging for personalized liver radiation therapy

Sirisha Tadimalla¹, Tim Wang², Val Gebski³, Sheryl Foster^4,5, Vincent Lam⁶, Jonathan Sykes², Robert Finnegan^1,7,8, Jacob George⁹, Verity Ahern², Steven Sourbron¹⁰, and Annette Haworth¹

¹Institute of Medical Physics, The University of Sydney, Sydney, Australia, ²Sydney West Radiation Oncology Network, Western Sydney Local Health District, Westmead, Australia, ³NHMRC Clinical Trials Centre, The University of Sydney, Sydney, Australia, ⁴Faculty of Medicine and Health, The University of Sydney, Sydney, Australia, ⁵Department of Radiology, Westmead Hospital, Westmead, Australia, ⁶Acute Surgical Unit, Westmead Hospital, Westmead, Australia, ⁷Ingham Institute of Applied Medical Research, Liverpool, Australia, ⁸Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Australia, ⁹Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, Australia, ¹⁰Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Cancer, Radiotherapy

Quantitative imaging biomarkers of liver function offer a potential opportunity to optimize radiation dose distributions for personalized treatment of patients with liver cancers using radiation therapy. The PRISM clinical study aims to determine if radiation treatment plans guided by liver function maps from MRI can increase the therapeutic dose to tumours. We have developed a dedicated multi-parametric MRI protocol for the quantitative assessment of liver composition, structure and function. Details of the protocol and pilot data are presented here.

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