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Abstract #4441

Toward Assessment of Renal Tubule Volume Fraction in Rat Kidney Using Decomposition of Parametric T2 Mapping

Ehsan Tasbihi1, Thomas Gladytz1, Ludger Starke1,2, Jason M. Millward1, Erdmann Seeliger3, and Thoralf Niendorf1,4
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, 2Hasso Plattner Institute for Digital Engineering, University of Potsdam, Potsdam, Germany, 3Institute of Translational Physiology, Charité – Universitätsmedizin, Berlin, Germany, 4Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the MAX Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Synopsis

Keywords: Kidney, Preclinical

Increased incidence of kidney diseases is a concern, for which rapid biomarkers are lacking. Changes in tubule volume fraction (TVF) is a potential biomarker for kidney disease. T2-mapping may be useful to asses TVF in noninvasive manner. To study this, we developed a protocol tailored for T2-mapping of the rat kidney, and determined a suitable numerical solution for multi-exponential decomposition of the T2-decay. Evaluation and validation of these algorithms using synthetic data and phantom showed an accuracy of 98%. This demonstrates that our approach is promising for research into quantitative assessment of renal TVF in in vivo applications.

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Abstract Presentation Video

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