Abstract #4451

APT histogram parameters for Response Prediction of Neoadjuvant Chemotherapy in Rectal Cancer: A Prospective Study

Xiaoling Gong¹, Yu Shen², Daguang Wen³, Xiaoxiao Zhang⁴, Xiaoyong Zhang⁵, Ziqiang Wang², and Bing Wu³

¹Department of Radiology, West China Hospital, Sichuan University, Cheng du, China, ²Colorectal Cancer Center，Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China, ³Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ⁴Philips Healthcare, China, Beijing, China, ⁵Philips Healthcare, China, Chengdu, China

Synopsis

Keywords: Cancer, fMRI, rectal cancerEarly imaging prediction of neoadjuvant chemotherapy (NACT) response would enable a personalized treatment approach to improve therapeutic response and avoid treatment morbidity in rectal cancer. Morphological changes base on T2 weighted MRI and free dispersion limitation of water molecules in tumor have limited value in evaluating efficacy after NACT. Amide proton transfer (APT)–weighted MRI, indirectly detecting the concentration of tissue macromolecular proteins, could help to inform us of the proliferation and biological status of tumor cells. The aim of this study is to determine if APT MRI is useful in early assessment of treatment response in persons with rectal cancer.

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