Abstract #4452

Comparison of fat fraction techniques within the pelvis: evaluating repeatability and accuracy

Yassine N Azma^1,2, Nada Boci¹, Katarzyna Abramowicz¹, Matthew R Orton^1,2, Nina Tunariu^1,2, Dow-Mu Koh^1,2, Geoff Charles-Edwards^1,2, David J Collins^1,2, and Jessica M Winfield^1,2

¹MRI Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom, ²Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom

Synopsis

Keywords: Fat, Whole Body, Dixon

Dixon-derived fat fraction (FF) has proven to play a pivotal role in whole-body MRI examinations for assessment of bone marrow disease in advanced prostate cancer. However, Dixon sequences are known to be subject to multiple sources of bias compared to the proton-density fat fraction (PDFF) gold standard. In this study, FF within the pelvis was measured for healthy tissues, active lesions and treated lesions with six different Dixon sequences. All sequences demonstrated good repeatability in scan-rescan studies of healthy volunteers. Statistically significant differences were observed between T₁w-FF and PDFF for both active and treated lesions which requires further investigation.

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