Abstract #4455

The Brain-Heart-Placenta Connection: Multimodal Investigation of Neurodevelopment in Mice with Congenital Heart Disease

Margaret Stapleton^1,2, Devin Raine Everaldo Cortes^2,3,4, Samuel Wyman^1,2, Cody Ruck^1,2, Shanim Manzoor^1,2, Gabriella M Saladino^1,2, George C Gabriel¹, Tuan Tuan Tan¹, Jiuann-Huey Lin^3,5, Sebastian Ho¹, Sivakama S. Bharathi⁶, Eric Goetzman⁶, Cecilia W. Y. Lo¹, Anthony G Christodoulou⁷, and Yijen L. Wu^1,2

¹Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsbrugh, PA, United States, ²Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, ³Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, ⁴Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, United States, ⁵Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, ⁶Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, ⁷Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Keywords: Heart, Fetus, Congenital Heart DiseaseNeurodevelopmental deficits (NDD) are a prevalent debilitating factor in patients with congenital heart disease (CHD) even after successful surgical palliation, but the etiology for NDD is not understood. Our study in a transgenic mouse model carrying causative genetic mutations found that NDD associated with CHD is not merely the consequence of compromised fetal hemodynamics, but primarily driven by intrinsic genetic factors and modulated by the placenta. Our study suggests that placental functions might potentially be a possible intervention strategy to overcome intrinsic genetic disadvantages.

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