Meeting Banner
Abstract #4456

Intra-subject repeatability and initial clinical evaluation of approximate myocardial spin-lock dispersion mapping

Joao Tourais1, Yidong Zhao1, Iain Pierce2, Christian Nitsche2, George D Thornton2, Mehmet Akcakaya3, Qian Tao1, Thomas A Treibel2, and Sebastian Weingartner1
1Imaging Physics, Delft University of Technology, Delft, Netherlands, 2Barts Heart Centre and Institute for Cardiovascular Science, University College London, London, United Kingdom, 3Department of Electrical and Computer Engineering and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Myocardium, Quantitative ImagingApproximate myocardial spin-lock (SL) dispersion mapping was obtained using simultaneous TRAFF2 and T2 mapping with good image quality and consistent repeatability among healthy subjects at 3T. Initial patient data indicates clinical feasibility and sensitivity to scar tissue, as identified by LGE. T2 and TRAFF2 are sensitive to distinct macromolecular interactions, showing differential contrast in disease. SL dispersion may exploit this and allow for isolating contrast components (e.g. chemical exchange effects). Our results suggest that these may allow for robust, complementary, and comprehensive clinical sensitivity to pathological remodeling. Future evaluation in a larger patient cohort with different myocardial injuries is warranted.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords