Abstract #4479

Diffusion spectrum imaging at 7T for probing Restricted compartment of Textile-based Phantom

Sudhir Kumar Pathak¹, Yijen Wu^2,3, Tony Zuccolotto⁴, and Walter Schneider^1,5,6,7,8

¹Learning Research and Development Center, University of Pittsburgh, Pittsburgh, PA, United States, ²Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, ³Rangos Research Center Animal Imaging Core, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Psychology Software Tools, Pittsburgh, PA, United States, ⁵Psychology, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ⁷Neurosurgery, University of Pittsburgh, Pittsburgh, PA, United States, ⁸Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Synopsis

Keywords: Phantoms, Quantitative Imaging, Diffusion MRI, microstructural imagingValidating mathematical models that describe the diffusion in the restricted compartment in biological tissue is an active research area. Techniques like NODDI, SMT, and CHARMED models claim to quantify restricted, hindered, and free water compartment but lacks validation on a typical clinical scanner. We present a 3D-printed phantom that uses (non)-water-filled textile-based hollow fiber with a 0.9μ diameter to validate restricted and hindered compartments. This study used a DSI-based scanning protocol and reconstruction method (GDSI and RDI) to probe the restricted compartment at a 2-6μ length scale. Scalar metrics derived from reconstruction methods show a significant difference between water-(un)filled taxons.

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