Abstract #4480

Investigating Diffusion Time Dependent Kurtosis Evolution in Repeated Mild Traumatic Brain Injury in Mice

Jake Hamilton^1,2, Naila Rahman^1,2, Kathy Xu³, Arthur Brown^3,4, and Corey Baron^1,2

¹Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, ²Centre for Functional and Metabolic Mapping (CFMM), Robarts Research Institute, University of Western Ontario, London, ON, Canada, ³Translational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, ⁴Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada

Synopsis

Keywords: Traumatic brain injury, Microstructure, mild Traumatic Brain Injury (mTBI); ConcussionProbing the diffusion time dependence of diffusional kurtosis within brain microstructure is being recognized as a valuable method to study various neurological pathologies, however, its use in the study of repeated mild traumatic brain injury (mTBI) has not been explored. In this work, we investigated differences in the time-dependence of diffusional kurtosis in injured and sham mice using oscillating gradient spin echo (OGSE) diffusion kurtosis imaging (DKI). The results of this work show promising differences in kurtosis within the hippocampus of injured and sham mice, illustrating the sensitivity of OGSE DKI in detecting long-lasting pathological microstructural changes following brain injury.

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