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Abstract #4493

The Value of Neurite Orientation Dispersion and Density MR Imaging in Diagnosing Temporal Lobe Epilepsy with Hippocampal Sclerosis

Xiaonan Zhang1, Guohua Zhao1, Huiting Zhang2, Eryuan Gao3, and Jingliang Cheng1
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2MR Scientific Marketing, Siemens Healthineers Ltd., Wuhan, China, 3The First Affiliated Hospital of Zhengzhou University,, Zhengzhou, China

Synopsis

Keywords: Quantitative Imaging, BrainThe hippocampal microstructural alterations by using routine magnetic resonance imaging presents a challenge. This study aimed to evaluate the performance of the NODDI models in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS) by comparison with the routine Flair sequence. Our results found that all NODDI parameters had significant differences between ipsilateral HS and contralateral HS/HC, and had better diagnostic performance than Flair sequence. In addition, combined NODDI model had significant better diagnostic performance than all the single parameters. In conclusion, NODDI is superior to Flair image in diagnosing TLE with HS.

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Keywords