Keywords: Quantitative Imaging, BrainThe hippocampal microstructural alterations by using routine magnetic resonance imaging presents a challenge. This study aimed to evaluate the performance of the NODDI models in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS) by comparison with the routine Flair sequence. Our results found that all NODDI parameters had significant differences between ipsilateral HS and contralateral HS/HC, and had better diagnostic performance than Flair sequence. In addition, combined NODDI model had significant better diagnostic performance than all the single parameters. In conclusion, NODDI is superior to Flair image in diagnosing TLE with HS.
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