Abstract #4498
Mapping transmit and receive B1 using variable flip angle acquisition on a person-by-person basis for hyperpolarized Carbon-13 and Xenon-129 MRI
Kylie Yeung1,2,3, Zack Ravetz1,4, Kher Lik Ng2,5, Gabriele AbuEid2, William Hickes2, Kenneth Jacob2, Mitchel Danisa2, Marianne Durrant2, Rebecca Mills1, Ayaka Shinozaki1,6, Jordan McGing1, Aaron Axford1, Sarah Birkhoelzer1, Rolf F Schulte7, Oliver Rider1, Anthony McIntyre2, Emily Fraser5, Damian J Tyler1,6, Fergus Gleeson2,8, and James T Grist1,2,6,9
1Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, 3Department of Oncology, Univeristy of Oxford, Oxford, United Kingdom, 4RRPPS, University Hospitals Birmingham, Birmingham, United Kingdom, 5Oxford Respiratory Service, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, 6Department of Physiology, Anatomy and Genetics, Univeristy of Oxford, Oxford, United Kingdom, 7GE Global Research, Munich, Germany, 8Department of Oncology, University of Oxford, Oxford, United Kingdom, 9Alama Mater Studorium, University of Bologna, Bologna, Italy
Synopsis
Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Non-Gas), Xenon-129, Carbon-13Hyperpolarized MRI allows the imaging of processes such as gas exchange and metabolism. Calibration of transmit and receive (Tx/Rx) B1 is required to account for coil inhomogeneities in reconstruction. A variable flip angle (VFA) method, which is fast and readily implemented, allows for a simultaneous B1/T1 measurement. In this study, a mathematical model of VFA calibration was developed, tested, validated in a hyperpolarized Carbon-13 (13C) phantom and in vivo with hyperpolarized Xenon-129 imaging of human lungs.
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