Abstract #4502

Terminal Airspace Enlargement Measured Using Pulmonary Functional MRI Predicts CT Airway Loss in COPD

Paulina Victoria Wyszkiewicz^1,2, Maksym Sharma^1,2, Harkiran K Kooner^1,2, David G McCormack³, Miranda Kirby⁴, and Grace Parraga^1,2,3,5

¹Department of Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Division of Respirology, Department of Medical Biophysics, Western University, London, ON, Canada, ⁴Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada, ⁵School of Biomedical Engineering, Western University, London, ON, Canada

Synopsis

Keywords: Hyperpolarized MR (Gas), LungThe onset and progression of chronic obstructive pulmonary disease (COPD) is currently believed to initiate in the small-airways and progresses to emphysema or terminal airspace (alveolar) enlargement and destruction. MRI apparent-diffusion-coefficient (ADC) provides a way to measure subclinical emphysematous destruction in patients. Here we investigated the relationship between pulmonary functional MRI measurements of terminal airspace enlargement using ³He MRI-ADC and CT airway changes in ex-smokers with COPD. MRI-ADC values at baseline were uniquely predictive of worsening CT total-airway-count and airway wall-area after three-years. MRI captures evidence of mild or subclinical emphysema and its relationship with terminal airway obliteration in COPD.

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