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Abstract #4503

Effect of glucose on the HP 129Xe dissolved phase blood resonances

Lutoslawa Mikowska1, Vira Grynko2,3, Yurii Shepelytskyi3,4, Iullian Constantin Ruset5, Joseph Deschamps6, Hannah Aalto6, Marta Targosz-Korecka1, Hubert Harańczyk1, Dilip Balamore7, and Mitchell Albert3,4,8
1Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland, 2Chemistry and Material Science Program, Lakehead University, Thunder Bay, ON, Canada, 3Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 4Chemistry Department, Lakehead University, Thunder Bay, ON, Canada, 5Xemed LLC, Durham, NH, United States, 6Applied Life Sciences Program, Lakehead University, Thunder Bay, ON, Canada, 7Department of Engineering/Physics/Technology, Nassau Community College, Garden City, NY, United States, 8Northern Ontario School of Medicine, Sudbury, ON, Canada

Synopsis

Keywords: Hyperpolarized MR (Gas), Spectroscopy, blood, hemoglobin, dissolved phase imaging

We examined the impact of elevated glucose levels on the chemical shift and T2* relaxation of hyperpolarized 129Xe dissolved in sheep blood. The addition of glucose did not affect the 129Xe-plasma resonance. For the first time, however, we have observed an additional 129Xe dissolved phase resonance attributed to 129Xe bound to glycated hemoglobin. A glucose-related linear downfield shift of the 129Xe resonance frequency was observed for 129Xe bound to native hemoglobin, whereas the T2* relaxation of 129Xe bound to glycated hemoglobin increased non-linearly with increasing glucose concentration.

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