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Abstract #4505

Hyperpolarized 129Xe Magnetic Resonance Dual Signal Probe Based on CB[6] Nanoparticles for Precise Drug Delivery Monitoring

Chenlu Yuan1, Qianni Guo1, Qingbin Zeng1, Yaping Yuan1, Weiping Jiang1, Chaohui Ye1, and Xin Zhou1
1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences – Wuhan National Laboratory for Optoelectronics, Wuhan 430071, P. R. China, WUHAN, China

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), 129Xe，Hyper-CESTWe synthesized an ultrasensitive 129Xe NMR probe with dual signals. It is a hollow nanoparticle composed of water-soluble CB[6]. It has two different hydrophobic cavities. Two 129Xe NMR signals with different chemical shifts can appear in a single detection, effectively avoiding the occurrence of false positive and false negative in complex biological environment detection, improving the accuracy and sensitivity of single detection, and has broad application prospects.

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Abstract

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