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Abstract #4509

Assessing Ventilation Dynamics of Lung Transplantation with Free-Breathing Hyperpolarized Xenon-129

Faraz Amzajerdian1, Hooman Hamedani1, Ryan Baron1, Mostafa Ismail1, Luis Loza1, Kai Ruppert1, Stephen Kadlecek1, and Rahim Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), LungRegional quantification of ventilation dynamics can provide valuable insights into the functional changes associated with both unilateral and bilateral lung transplantation, potentially improving diagnostic monitoring and providing a better understanding of underlying pathophysiology. By imaging hyperpolarized xenon-129 (HXe) continuously over an extended period of time, ventilation dynamics more representative of steady-state, physiological breathing were derived and used to assess differences between unilateral and bilateral transplant patients.

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Keywords