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Abstract #4517

Improved Robustness for Deep Learning-based Segmentation of Perfusion CMR Using Data Adaptive Uncertainty-guided Spatiotemporal Analysis

Dilek Mirgun Yalcinkaya1,2, Khalid Youssef3, Bobak Heydari4, Subha Raman3,5, Rohan Dharmakumar3,5, and Behzad Sharif1,3,5
1Laboratory for Translational Imaging of Microcirculation, Indiana University (IU) School of Medicine, Indianapolis, IN, United States, 2Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 3Krannert Cardiovascular Research Center, IU School of Medicine/IU Health Cardiovascular Institute, Indianapolis, IN, United States, 4Stephenson Cardiac Imaging Centre, Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada, 5Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Machine Learning/Artificial Intelligence, SegmentationWe proposed and validated Data Adaptive Uncertainty-Guided Spatiotemporal (DAUGS) analysis that leverages the data-driven uncertainty map of the segmentation contours among a pool of trained deep neural networks (DNNs) and automatically selects the segmentation result with the highest level of certainty. Our results suggest that proposed DAUGS and standard DNN-based analysis demonstrated on-par performance on the internal test set which is from the same institution as training set and acquired with FLASH sequence. In contrast, DAUGS analysis considerably outperformed DNN-based analysis on the external test set which was acquired with a bSSFP pulse sequence at a different institution, demonstrating the improved robustness of the proposed method despite limited training data.

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