Abstract #4532

3D T2 and T1ρ Mapping of Ischemic Injury to the Femoral Head: An In Vivo Piglet Model Study

Erick O. Buko^1,2, Douglas Albrecht¹, Alexandra R. Armstrong¹, Ferenc Tóth¹, and Casey P. Johnson^1,2

¹Veterinary Clinical Sciences, University of Minnesota, Saint Paul, MN, United States, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Bone, IschemiaLegg-Calvé-Perthes disease (LCPD) is a pediatric hip disorder caused by femoral head ischemia and osteonecrosis. In this work, we investigated whether 3D T2 and T1ρ relaxation time mapping are sensitive to ischemic injury to the bone and marrow of the femoral epiphysis and metaphysis following surgical induction of femoral head ischemia in a piglet model of LCPD. We found that T2 and T1ρ increased in the ischemic femoral epiphysis and decreased in the perfused metaphyseal spongiosa. Our findings support the potential clinical use of T2 and T1ρ mapping to assess the severity of femoral head injury in patients with LCPD.

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