Abstract #4533

Can Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequences Detect Signal from Collagen Backbone Protons?

Dina Moazamian¹, Xiaojun Chen¹, Arya Suprana¹, Andrew Andrew Xia¹, Saeed Jerban¹, Bhavsimran Malhi¹, Michael Carl², Eric Y Chang^1,3, Yajun Ma¹, Hyungseok Jang¹, and Jiang Du^1,3,4

¹Radiology, University of California San Diego, San Diego, CA, United States, ²Radiology, GE Healthcare, San Diego, CA, United States, ³VA San Diego Healthcare System, San Diego, CA, United States, ⁴Bioengineering, University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Bone, BoneUltrashort echo time (UTE) and zero echo time (ZTE) sequences have been extensively investigated for imaging of short T2 species. The ZTE sequence has a shorter effective TE than UTE and may be superior in imaging ultrashort T2 species. This study investigated whether ZTE could directly image collagen backbone protons in bovine cortical bone and human patellar tendon samples after D2O exchange and freeze-drying. Our experimental results demonstrate that collagen backbone protons are "invisible" with ZTE, which may not be able to directly image species with T2s of ~10 µs.

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