Abstract #4539

Investigation of the fat-bone-muscle connection in osteoporosis and osteoarthritis by 1H MRS

Alessandra Maiuro^1,2, Daniele Mattioli², Guglielmo Manenti³, Elena Gasbarra⁴, Umberto Tarantino⁴, and Silvia Capuani^1,2

¹Physics, CNR Institute for Complex Systems (ISC), Rome, Italy, ²Physics, Sapienza University of Rome, Rome, Italy, ³Diagnostic and Interventional Radiology, Molecular Imaging and Radiotherapy, Policlinico Tor Vergata Foundation, Tor Vergata University of Rome, Rome, Italy, ⁴Orthopedics and Traumatology, Policlinico Tor Vergata Foundation, Tor Vergata University of Rome, Rome, Italy

Synopsis

Keywords: Bone, Spectroscopy, Osteoporosis, Fatty acids, Osteoarthritis, MuscleThe metabolic pathways involved in the development of osteoporosis and osteoarthritis, was investigated by SVS1H MRS. Metabolites and fatty acids of the bone marrow and the adjacent muscle of healthy, osteoporotic and osteoarthritic woman were quantified using LCModel. The increase of E23 resonance in muscles is a potential marker of sarcopenia correlated to osteoporosis. The decrease of the L53 resonance in bone marrow highlights the presence of osteoporosis (together with total lipids increase) or osteoarthritis (together with bone marrow water increase).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.