Abstract #4542

A multiscale approach based on the combination of DTI, XRD and histology to study the myeloarchitecture in a rat model of mTBI

Michela Fratini^1,2, Isabel San Martín Molina³, Manfred Burghammer⁴, Tilman Grünewald^4,5, Raimo A. Salo³, Omar Narvaez³, Maria Guidi⁶, Federico Giove⁶, Manisha Aggarwal⁷, Jussi Tohka³, Alejandra Sierra³, and Gaetano Campi⁸

¹Nanotec, CNR, Roma, Italy, ²IRCSS Santa Lucia Foundation, Roma, Italy, ³University of Eastern Finland,, Kuopio, Finland, ⁴European Synchrotron Radiation Facility, Grenoble, France, ⁵Aix-Marseille Université, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France, ⁶Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Rome, Italy, ⁷Russell H. Morgan Department of Radiology and Radiological Science, , John Hopkins University School of Medicine, Baltimore, MD, United States, ⁸Institute of Crystallography, CNR, Rome, Italy

Synopsis

Keywords: Multimodal, Tissue Characterization, x ray scanning diffractionWe have combined high-resolution structural imaging techniques, such as scanning micro-X-ray diffraction (SμXRD), DTI and histology to study the myeloarchitecture in both healthy and pathological rat brains. For the latter, we focused on an animal model of mild traumatic brain injury (mTBI) that is the most common form of acquired brain injury caused by an external force into the brain. We have performed a quantitative morphometrical analysis of myelin, mapping its relevant morphological and topological parameters (period, orientation, and integrated intensity fluctuation) to assess tissue microstructural damage 35 days after mTBI and sham-operation

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