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Abstract #4596

EPG-based optimization of the SNR of the phase-cycled bSSFP in phase-based electrical conductivity mapping

Julien Lamy1, Flavy Savigny1, and Paulo Loureiro de Sousa1
1ICube, Université de Strasbourg-CNRS, Strasbourg, France

Synopsis

Keywords: Signal Modeling, SimulationsPhase-based electrical conductivity mapping requires high SNR due to the instability of the reconstruction. Electrical conductivity can be measured by the phase-cycled bSSFP, a high-SNR sequence which is also weighted by other biophysical parameters but for which no complete analytical model exist. In this work, we use EPG-based simulations to investigate how the bSSFP signal varies with the flip angle, the phase step and the pulse duration in a diffusive, two-pools model of the brain white matter at 3 T. We show that our simulations agree with in-vivo acquisitions and establish guidelines to optimize the SNR of the phase-cycled bSSFP.

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