Abstract #4597

Estimation of the Spatial Gradient of the MR Image from the Diffusion Profile

Iman Aganj^1,2, Matthew Vera¹, Thorsten Feiweier³, Andre J. van der Kouwe^1,2, John E. Kirsch^1,2, and Bruce R. Fischl^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Radiology Department, Harvard Medical School, Boston, MA, United States, ³Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Signal Modeling, Diffusion Tensor ImagingIn the course of diffusion, water molecules experience varying values for the relaxation-time property of the underlying tissue, a factor that has not been accounted for in diffusion MRI (dMRI) modeling. Accordingly, we derive a relationship between the diffusion profile measured by dMRI and the spatial gradient of the image, and subsequently estimate the latter from the former. We test our hypothesized relationship via dMRI of the human brain (a public in vivo image and an acquired ex vivo stimulated-echo image), showing statistically significant results that may be due to our model and/or the confounding factor of “fiber continuity”.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.