Abstract #4601

Impact of free-water correction on white matter changes measured by diffusion tensor imaging in migraine

Irene Guadilla^1,2, Ana Fouto¹, Álvaro Planchuelo-Gómez³, Antonio Tristán-Vega³, Amparo Ruiz-Tagle¹, Inês Esteves¹, Gina Caetano¹, Nuno Silva⁴, Pedro Vilela⁵, Raquel Gil-Gouveia^6,7, Santiago Aja-Fernández³, Patrícia Figueiredo¹, and Rita Nunes¹

¹Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, ²Universidad Autónoma de Madrid, Madrid, Spain, ³Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain, ⁴Learning Health, Hospital da Luz, Lisbon, Portugal, ⁵Imaging Department, Hospital da Luz, Lisbon, Portugal, ⁶Neurology Department, Hospital da Luz, Lisbon, Portugal, ⁷Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisbon, Portugal

Synopsis

Keywords: Signal Modeling, Diffusion/other diffusion imaging techniquesMenstrual migraine affects about 25% of female migraine patients. However, the diagnosis of migraine is particularly difficult because the brain changes associated with migraine are challenging to detect with imaging techniques. Diffusion-weighted MRI (dMRI) permits the detection of alterations in the microenvironment of the brain tissues. We investigate whether removing the contribution of the free water component from the diffusion-signal can provide increased sensitivity to identify white matter changes in migraine using diffusion tensor metrics.

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