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Abstract #4607

Calibration of R2' relaxation rate and hepatic iron concentration by Monte Carlo simulations

Xiaoben Li1, Mengyuan Ma1, Jinyang Wang1, Junying Cheng2, Wenjun Yao3, and Changqing Wang1
1School of Biomedical Engineering, Anhui Medical University, Hefei, China, 2Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 3Department of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China

Synopsis

Keywords: Signal Modeling, LiverThe R2' relaxation rate is expected to become a more specific biomarker in hepatic iron overload because it is not affected by pathological factors. However, calibrating the relationship between R2' relaxation rate and hepatic iron concentration (HIC) at different field strengths is time-consuming. In this work, we develop Monte Carlo simulations to investigate relationship between R2' relaxation rate and HIC in hepatic iron overload at both 1.5T and 3.0T. Results show strong linear relationships between R2' predictions and HIC. The Monte Carlo simulations may greatly shorten the clinical calibration time of MRI relaxation rates and HIC.

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