Abstract #4643

Comparison of Compressed Sensing Accelerated Rosette UTE and Conventional 31P 3D MRSI at 3T in Leg Muscle

Brian Bozymski¹, Xin Shen², Ali Caglar Ozen³, Serhat Ilbey³, Albert Thomas⁴, Mark Chiew⁵, William Clarke⁵, Ulrike Dydak^1,6, and Uzay Emir^1,7

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Department of Radiology and Radiotherapy, Medical Center - University of Freiburg, Freiburg, Germany, ⁴Department of Radiology, University of California, Los Angeles, CA, United States, ⁵Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁶Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ⁷Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Data Acquisition, MuscleQuantitative comparison of novel, rosette trajectory UTE (70 μs) and conventional weighted Cartesian 3D 31P MRSI sequences is performed at 3T in quadriceps muscle. After previous validation, five healthy volunteers were scanned by both sequences without interruption. Fitted metabolite maps and SNR calculations of PCr and ATP signals across selected slices and voxels displayed competitive performance between each acquisition. Retrospective compressed sensing (CS) acceleration results suggest this UTE MRSI may enable faster, higher resolution 31P metabolite mapping in leg muscle and other organs of interest.

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