Abstract #4655

MRI of the diaphragm: characterizing motion and microstructural properties in ICU patients

Myrte Wennen^1,2, Tim J. Marcus³, Annemijn Jonkman¹, Lilian Meijboom³, Marc Kachelriess⁴, Yannick Berker^5,6,7, Gustav J. Strijkers³, Coen A. C. Ottenheijm⁸, Leo M. A. Heunks¹, Aart J. Nederveen³, and Oliver J. Gurney-Champion³

¹Intensive Care, Erasmus Medical Centre, Rotterdam, Netherlands, ²Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Rotterdam, Netherlands, ³Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁴Division of X-Ray imaging and CT, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Hopp Children's Cencer Center Heidelberg (KiTZ), Heidelberg, Germany, ⁶Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany, ⁷National Center for Tumor Diseases (NCT), Heidelberg, Germany, ⁸Department of Physiology, Amsterdam University Medical Centers, Amsterdam, Netherlands

Synopsis

Keywords: Lung, Motion Correction, DiaphragmDiaphragm weakness is common in intensive care patients and has a detrimental effect on clinical outcome. Weakness in these patients may be explained by disuse atrophy or injury resulting from systemic inflammation among other factors. MRI can be used to study the motion and tissue characteristics of the diaphragm. We present the design of an MRI protocol for quantifying motion and tissue characteristics of the diaphragm. 4D MRI, relaxometry and dynamic contrast enhanced MRI were successfully applied in healthy volunteers and COVID-19 patients. Our method may aid in finding treatments and prevention strategies for diaphragm weakness in critically ill patients.

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