Abstract #4658

Motion-resolved pulmonary imaging for simultaneous fractional ventilation and T1 mapping using MR Multitasking

Chaowei Wu^1,2, Hsu-Lei Lee¹, Nan Wang^1,3, Fei Han⁴, Vibhas Deshpande⁵, Andreas Voskrebenzev⁶, Jens Vogel-Claussen⁶, Anthony G Christodoulou^1,2, Yibin Xie¹, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Radiology Department, Stanford University, Stanford, CA, United States, ⁴Siemens Healthcare, Los Angeles, CA, United States, ⁵Siemens Healthcare, Austin, TX, United States, ⁶Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Lung, Quantitative Imaging

Pulmonary imaging has taken on greater importance during the COVID-19 pandemic. Regional fractional ventilation (FV) and T1 from MR imaging are potential biomarkers for pulmonary tissue and functional abnormality. However, FV imaging is limited to 2-D acquisition or 3-D with low spatial resolution, and T1 imaging typically requires long breath-holding that is not practical in many scenarios. Furthermore, there is no existing technique for simultaneous acquisition of both pieces of information. To address these limitations, we propose a novel motion-resolved pulmonary imaging technique for simultaneous FV and T1 mapping using MR Multitasking, and demonstrate its feasibility in 7 healthy volunteers.

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