Abstract #4661

Investigating the Relationship between Lung Volume and the Lung-Diaphragm Signal at 3T: Implications for Ventilation Measures

Zachary Peggs^1,2, Jonathan Brooke², Jan Paul¹, Christopher Bradley¹, Andrew Cooper¹, Charlotte E Bolton², Ian P Hall², Susan Francis^1,2, and Penny Gowland^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre (BRC), Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Lung, Data Analysis, COPD

The relationship between lung volume and lung MR signal is key to quantifying ventilation using ¹H MRI. This relationship was probed using a highly accelerated 3D FFE acquisition at 3T. Linear regression between the percentage change in lung-diaphragm navigator signal and lung volume showed that the relationship between these parameters was not always linear, especially in patient groups. Polynomial regression was used to assess the extent of the hysteresis between inspiration and expiration, with more hysteresis observed in chronic obstructive pulmonary disease (COPD) patients.

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