Abstract #4662

Functional Pulmonary Proton MRI: Voxel-wise Linear-fitting Ventilation (VOLVE) Assessment in Chronic Obstructive Pulmonary Disease (COPD)

Zachary Peggs^1,2, Jonathan Brooke², Jan Paul¹, Christopher Bradley¹, Andrew Cooper¹, Charlotte E Bolton², Ian P Hall², Susan Francis^1,2, and Penny Gowland^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre (BRC), Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Lung, Quantitative Imaging, COPD

The VOLVE (VOxel-wise Linear fit VEntilation, VOLVE) method,whereby voxel-wise linear fitting between the lung-diaphragm navigator signal and lung parenchyma MR signal is used to assess regional ventilation, was investigated in chronic obstructive pulmonary disease (COPD) and alpha-1 antitrypsin deficiency (A1ATD). Fractional ventilation (FV) maps derived from phase-resolved functional lung imaging (PREFUL) were also determined. Significant differences between the healthy and the lung disease groups were found, indicating the sensitivity of these techniques to emphysematous lung disease.

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