Abstract #4665

Local correlation of echo-time dependent observed lung T1 and quantitative perfusion in patients with chronic obstructive pulmonary disease

Simon Michael Florian Triphan^1,2, Marilisa Konietzke^1,2,3, Jürgen Biederer^1,2,4,5, Hans-Ulrich Kauczor^1,2, Claus Peter Heußel^1,6, and Mark Oliver Wielpütz^1,2

¹Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany, ²Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany, ³Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, ⁴Faculty of Medicine, University of Latvia, Riga, Latvia, ⁵Christian-Albrechts-Universität zu Kiel, Kiel, Germany, ⁶Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany

Synopsis

Keywords: Lung, Quantitative Imaging, T1 mapping, perfusion quantification, UTEObserved TE-dependent T1 has been shown to correlate with MRI perfusion scores. Here, 22 patients with COPD were examined using DCE MRI and 2D UTE. Perfusion and T1(TE) was quantified based on these, respectively. Correlations of T1(TE) with perfusion measures were examined, with the strongest inter-patient correlation at TE₂=500μs but stronger local correlations at TE₁=70μs and TE₃=1200μs than at TE₂. The average T1 in defect areas according to DCE was shorter than in normal areas, with the smallest difference at TE₂. This implies that the local TE-dependence in defect voxels is further away from previously published behaviour in healthy volunteers.

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