Abstract #4666

Dynamic single slice 2D coronal lung MRI detects metronome-paced tachypnea (MPT) - induced hyperinflation in COPD patients

Robin Aaron Müller^1,2, Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Lea Behrendt^1,2, Till Frederik Kaireit^1,2, Julian Magnus Wilhelm Glandorf^1,2, Maximilian Zubke^1,2, Marius Wernz^1,2, Agilo Luitger Kern^1,2, Martin R. Prince^3,4, Christopher B. Cooper⁵, R. Graham Barr⁶, Jens M. Hohlfeld^2,7,8, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States, ⁵Departments of Medicine and Physiology, David Geffen School of Medicine, Los Angeles, CA, United States, ⁶Department of Medicine, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United States, ⁷Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, ⁸Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany

Synopsis

Keywords: Lung, Lung, COPDMetronome-paced tachypnea (MPT) is a technique where a patient breathes rapidly with a fixed frequency (40 breaths / minute). MPT induces dynamic hyperinflation and allows investigation of potential stress-driven effects on ventilation parameters. Fifteen patients with chronic obstructive pulmonary disease (COPD) and thirty healthy subjects underwent MRI with a 2D coronal lung MR image acquired repeatedly with a temporal resolution of 200 ms during resting tidal breathing (RTB) and MPT. The decrease of fractional ventilation (FV) and the increase of end-expiratory lung area (EELA) during MPT was significantly higher in COPD patients compared to respective healthy subjects.

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