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Abstract #4669

Detection of Emphysema using Phase-Resolved functional Lung Imaging Parametric Response Mapping (PREFULPRM)

Andreas Voskrebenzev1,2, Till Frederik Kaireit1,2, Marcel Gutberlet1,2, Filip Klimeš1,2, Lea Behrendt1,2, Hoen-oh Shin1,2, Hans-Ulrich Kauczor3,4, Tobias Welte2,5, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Medical School Hannover, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany, 4Translational Lung Research Center Heidelberg (TLRC), Member of the German Lung Research Center (DZL), Heidelberg, Germany, 5Clinic of Pneumology, Medical School Hannover, Hannover, Germany

Synopsis

Keywords: Lung, Data Processing

Ventilation measurements using signal differences between expiratory and inspiratory respiration states gained popularity as a biomarker for ventilation abnormalities. One method, which incorpartes such measurements is Phase-resolved functional lung imaging (PREFUL). A further classification of abnormalities such as emphysema and air-trapping beyond the current gas-exchange measurement is desirable. Therefore a MR adaption of CT’s parametric-response mapping (CTPRM) method is proposed as an additional post-processing method for PREFUL. The analysis of 34 patients with chronic obstructive pulmonary disease (COPD), shows that there is a high regional (Overlap normal 91%) and total lung concordance (r>0.86) for the proposed method PREFULPRM and CTPRM.

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