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Abstract #4672

Comparison of ventilation defects quantified by Technegas V-SPECT and hyperpolarized 129Xe MRI

Nisarg Radadia1, Yonni Friedlander2,3, Norman B Konyer2, Mobin Jamal1, Chynna Huang3, Troy Farncombe 4,5, Christopher Marriott 4,5, Christian Finley3,6,7, John Agzarian3,6,7, Myrna Dolovich1,2,3, Michael D Noseworthy 2,4,8, Parameswaran Nair1,3, Yaron Shargall3,6,7, and Sarah Svenningsen1,2,3
1Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada, 2Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 4Department of Radiology, McMaster University, Hamilton, ON, Canada, 5Department of Nuclear Medicine, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 6Division of Thoracic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada, 7Division of Thoracic Surgery, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 8Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas)Previous studies have demonstrated the comparability of ventilation assessed by SPECT and hyperpolarized gas MRI methods; however, these comparisons were qualitative and limited to visual scoring methods based on radiologist reporting. Thus, we quantified the relationship between ventilation-defect-percent (VDP) assessed from same-day Technegas ventilation-SPECT and hyperpolarized 129Xe MRI, in patients with early-stage lung cancer. We observed that ventilation defects quantified by Technegas V-SPECT and 129Xe MRI VDP were correlated and increased in patients with COPD. A bias towards higher Technegas V-SPECT VDP was detected and may be explained by differences in contrast agent properties, image acquisition conditions, and/or quantification pipelines.


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