Abstract #4673

Effect of Kaftrio therapy on pulmonary ventilation derived by 3D phase-resolved functional lung MRI in cystic fibrosis patients

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Milan Speth^1,2, Robert Grimm³, Martha Dohna¹, Gesine Hansen^2,4, Frank Wacker^1,2, Diane Renz¹, Anna-Maria Dittrich^2,4, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁴Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Lung, LungKaftrio therapy was shown to improve global clinical ventilation parameters in cystic fibrosis (CF) patients. 3D phase-resolved functional lung (PREFUL) MRI offers a contrast-free assessment of pulmonary ventilation during free breathing. The aim of this study was to determine whether 3D PREFUL parameters are suitable to measure response to Kaftrio therapy and their association with clinical outcomes in CF patients. All assessed MRI and clinical parameters significantly improved after initiation of Kaftrio. Relative change between baseline and post-treatment scans of 3D PREFUL ventilation defect percentage maps was in agreement with forced expiratory volume in 1 second and lung clearance index.

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