Keywords: Lung, Hyperpolarized MR (Gas)Hyperpolarized 129Xe gas MRI (XeMRI) is gaining traction globally as a primary endpoint in clinical trials, however it is unknown how images and measurements directly compare across different MRI scanner platforms. Here we compared same-day ventilation XeMRI across two MRI manufacturers at two sites in Vancouver Canada in patients with cystic fibrosis and healthy controls, to determine the interoperability across MRI platforms. Between-site ventilation images showed strong spatial overlap, and quantitative ventilation defect percent measurements showed strong agreement across all participants. These results support the use of XeMRI in multi-center studies irrespective of MRI platform.
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