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Abstract #4679

Assessment of early anthracycline-induced cardiotoxicity using segmental strain of cardiac magnetic resonance : an animal study

junqi liu1, qianfeng luo1, wanyin qi1, zhengyuan xiao1, xiaoyong zhang2, xingyuan kou1, and jing chen1
1The Affiliated Hospital of Southwest Medical University, Luzhou, China, 2Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China

Synopsis

Keywords: Cardiomyopathy, CardiomyopathyThis study investigated segmental strain to evaluate early anthracycline-induced cardiotoxicity on a 1.5T MR system in New Zealand rabbits models. The apical lateral wall and the anterior apical wall have a statistical difference corresponding to the pathological results in the second week. The ejection fraction showed statistical difference at the eighth week, while the global strain was not even statistically significant. The result showed that the peak segmental strain was earlier than the peak global strain and cardiac function, which may provide an effective and convenient monitoring method for chemotherapy patients.

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