Abstract #4690

Cardiovascular MRI combined with catheterization for objective assessment of cardiac function: data- and model-derived pressure-volume loops

Maria Gusseva^1,2,3, Daniel A. Castellanos⁴, Tarique Hussain¹, Dominique Chapelle^2,3, and Radomír Chabiniok^1,2,3,5

¹Department of Paediatrics, UT Southwestern Medical Center, Dallas, TX, United States, ²Inria, Palaiseau, France, ³Ecole Polytechnique, Palaiseau, France, ⁴Department of Cardiology, Boston Children’s Hospital, Boston, MA, United States, ⁵Czech Technical University in Prague, Prague, Czech Republic

Synopsis

Keywords: Heart, ModellingClinical pressure-volume data are often subjected to measurement noise. In the present work we explore the potential of a biomechanical model of the heart as a data-filtering tool. We use cardiovascular MRI volume data either simultaneously or sequentially acquired with catherization. We use time-varying elastance metrics for a quantitative comparison of data- and model-derived pressure-volume loops (PV loops). Our results demonstrate that the biomechanical model provides high quality PV loops that could be used to replace noisy data signals. In addition, this work contributes to the increased understanding of cardiovascular MRI results.

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