Keywords: Cardiomyopathy, Cardiovascular, energeticsCardiac energetics in patients with heart failure with preserved ejection fraction (HFpEF) may serve as a useful biomarker of disease status and therapeutic intervention. To evaluate the potential suitability of this endpoint as a biomarker in preclinical research, we assessed cardiac energetics in the ZSF1 obese rat model of HFpEF and ZSF1 lean control. This preclinical HFpEF model exhibited similar cardiac energetic deficits as do humans with HFpEF, indicating that that the PCr/γATP ratio may be a useful translational biomarker of disease status and intervention.
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