Abstract #4707

From Survival to Survivorship: Cardiac MRI and Serum Biomarkers of Early Detection and Therapy for Doxorubicin-Induced Cardiotoxicity in Mice

Margaret Caroline Stapleton^1,2, Elizabeth Mazzella^1,3, Noah Coulson^1,2, George Cater⁴, Kristina Schwabb^5,6, Sean Hartwick^5,6, Thomas Becker-Szurszewski^5,6, Devin Rain Everaldo Cortes^1,2,7, and Yijen L. Wu^1,2

¹Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, ²Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, ³Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States, ⁴St. Clair Hospital, Pittsburgh, PA, United States, ⁵Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh PA, Pittsburgh, PA, United States, ⁶Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, ⁷Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, United States

Synopsis

Keywords: Cardiomyopathy, ToxicityAnthracycline, like Doxorubicin (DOX), induced cardiotoxicity is a major cause of morbidity among childhood cancer survivors. Prior clinical studies diagnose using isolated measures of cardiac function, but by the time cardiotoxicity is detected, irreversible damage has already occurred. We hypothesize that multi-parametric cardiac MRI (CMR), and concurrent treatment with cardioprotective agents is a more sensitive biomarker for early diagnosis of DOX-induced cardiotoxicity. We identified DOX cardiotoxicity by CMR derived LV strain and Luminex biomarker analysis prior to any decrease in EF and SV. Our study suggests multi-parametric CMR with concurrent cardioprotective treatment can be a surrogate endpoint for therapeutic efficacy.

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