Keywords: Cardiomyopathy, Heart, Hear efficiencyNearly 70% of heart attacks (myocardial infarctions, MI) cases lead to a condition known as heart failure (HF), where the left ventricle (LV) remodels. Previous alginate and stem cell intramyocardial injection studies reported mixed outcomes using the LV global volumetric function and local myocardium mechanical response (strains and stresses)1,2. Such measures involve unvalidated assumptions yielding erroneous results3. We conducted a swine HF study treated with a particular alginate intramyocardial injection; however, instead of using the mechanical response, we directly measured the metabolic energy consumed by the myocardium before and after treatment using Positron emission tomography–magnetic resonance images (PET-MRI)4.
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