Abstract #4717

Dual responsive MR probe based on oxidation-triggered chemical shift

Natalia Ziolkowska^1,2, Katerina Sulkova¹, Lucie Kracikova³, Martin Vit¹, Richard Laga³, and Daniel Jirak¹

¹Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²First Faculty of Medicine, Institute of Biophysics and Informatics, Charles University, Prague, Czech Republic, ³Department of Polymer and Colloid Immunotherapeutics, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic

Synopsis

Keywords: Non-Proton, Tumor

Presented novel phosphorus- and fluorine-containing polymer possess high sensitivity at ³¹P/¹⁹F-MR and a large chemical shift from biological phosphorus signal (∆δ=60 ppm) due to phosphorothioate P=S group in its structure. The probe represents a conceptually new approach for phosphorus MR, as it undergoes oxidation-induced structural changes in the presence of ROS, represented in greater amounts in cancer tissue. The additional ¹⁹F-MR signal serve as an on-site information on the polymer distribution in the organism.

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