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Abstract #4719

7-T 39K/23Na MRI for assessment of ionic balance in patients exhibiting hypokalemic periodic paralysis

Claudius Sebastian Mathy1,2, Armin Michael Nagel1,3, Matthias Türk4,5, Michael Uder1, Rafael Heiß1, Marc-André Weber6, and Lena Vanessa Gast1
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States, 3Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 5Centre for Rare Diseases Erlangen (ZSEER), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 6Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, Rostock, Germany

Synopsis

Keywords: Non-Proton, Muscle, PotassiumCombined 39K/23Na MRI at 7T has become feasible recently after technical advances of 39K MRI. Here we assessed ion homeostasis alterations, especially tissue potassium and sodium concentrations (TPC/TSC) in a small pilot cohort of patients of hypokalemic periodic paralysis (HypoPP). Depending on the severity of fatty involvement of muscles, TSC was elevated in slightly to moderately involved muscles and TPC showed a tendency to decrease in an inverse correlated fashion. Almost entirely fatty infiltrated muscle showed a decrease of TSC and TPC. Therefore, combined 39K/23Na MRI could help to examine the pathophysiological processes in HypoPP and other muscular channelopathies.

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