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Abstract #4720

Spatially resolved assessment of 31P metabolite levels in liver metastases with 31P MRSI at 7T

Lieke van den Wildenberg1, Bobby Runderkamp2, Leonard Seelen1, Hanneke van Laarhoven3,4, Mark Gosselink1, Wybe van der Kemp1, Nadia Haj Mohammad5, Dennis Klomp1, and Jeanine Prompers1
1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 3Department of Medical Oncology, Amsterdam UMC, Amsterdam, Netherlands, 4Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands, 5Department of Medical Oncology, Utrecht Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Non-Proton, CancerMethods for early treatment response evaluation to systemic therapy of liver metastases are lacking. Tumor tissue is characterized by an increased PME/PDE ratio. However, with commonly used 31P surface coils for liver 31P MRS, the liver is not fully covered. Using an integrated 31P whole-body transmit coil in combination with a 16-channel body receive array at 7T, we were able to spatially map 31P metabolite levels throughout the whole liver in a patient with liver metastases. We found highly elevated levels of both PE/ATP and PC/ATP in liver metastases in comparison with healthy liver tissue.

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